Lipopolysaccharide (LPS) and its binding protein (LPS binding protein or LBP) are increased in the blood of obese persons relative to lean controls, and as they are produced by gram negative bacteria in the gut it is thought that this increase is due to increased gut permeability.
LPS has proinflammatory mechanisms to promote obesity and insulin resistance Probiotics can lower this LPS. Probiotics are live bacteria and yeasts that are good for your health, especially your digestive system. We usually think of bacteria as something that causes diseases. But your body is full of bacteria, both good and bad. Probiotics are often called “good” or “helpful” bacteria because they help keep your gut healthy.
Probiotics are naturally found in your body. You can also find them in some foods and supplements.
How Do They Work?
Researchers are trying to figure out exactly how probiotics work. Here are some of the ways they may keep you healthy:
•When you lose “good” bacteria in your body (like after you take antibiotics, for example), probiotics can help replace them.
•They can help balance your “good” and “bad” bacteria to keep your body working like it should.
What Do They Do?
Probiotics help move food through your gut. Researchers are still trying to figure out which are best for certain health problems.
Some common conditions they treat are:
•Irritable bowel syndrome
•Inflammatory bowel disease (IBD)
•Infectious diarrhea (caused by viruses, bacteria, or parasites)
There is also some research to show they help with problems in other parts of your body. For example, some people say they have helped with:
•Skin conditions, like eczema
•Urinary and vaginal health
•Preventing allergies and colds
Gut Bacteria May Affect Body Weight Regulation
There are hundreds of different microorganisms in your digestive system.The majority of these are bacteria, most of which are friendly. Friendly bacteria produce several important nutrients, including vitamin K and certain B-vitamins.They also help break down fiber that the body can’t digest, turning it into beneficial short-chain fatty acids like butyrate (6).
There are two main families of good bacteria in the gut: bacteroidetes and firmicutes. Body weight seems be related to the balance of these two families of bacteria (7, 8). Both human and animal studies have found that normal-weight people have different gut bacteria than overweight or obese people (9, 10, 11).
In those studies, people with obesity had more firmicutes and fewer bacteroidetes, compared to normal-weight people.There are also some animal studies showing that when the gut bacteria from obese mice are transplanted into guts of lean mice, the lean mice get fat (11).
All of these studies suggest that gut bacteria may play a powerful role in weight regulation.